The presence of microalgae in drinking water supply can cause significant disturbances. The process water clarification (coagulation/flocculation/dissolved air flotation, C/F/DAF) are used due to good efficiency for removal this contaminant. As a future strategy, the application of natural coagulants to water treatment emerges as a promising ecologically and socially sustainable option. Thus, the aim of this work is the application of the C/F/FAD process with Moringa oleifera seeds to removal Microcystis aeruginosa from water. For the tests it was used a synthetic water by deionized water with M. aeruginosa inoculum in cultive medium ASM-1. C/F/DAF tests it was used the "flotest" equipment. It was verified the efficiency of two types of coagulants based on M. oleifera seeds: full powder and defatted powder with ethanol. The results shown that M. oleifera defatted seeds were better to removal chlorophyll-a (91%), color (72%), turbidity (77%) and UV254nm (45%) from water than M. oleifera full powder seeds that shown removal from cholophyll-a, color, turbidity and UV254nm about 82%, 60%, 64%, 28%, respectively. It was observed that residual values of dissolved organic carbon (DOC) were increased in the water treated for the both coagulants based M. oleifera, being the defatted seeds shown lightly larger (14,5 mg.L-1) than the full seeds (12,4 mg.L-1).